Antimicrobial peptide shows enhanced activity and reduced toxicity upon grafting to chitosan polymers.
نویسندگان
چکیده
Here we report that grafting of a short antimicrobial peptide, anoplin, to chitosan polymers is a strategy for abolishing the hemolytic propensity, and at the same time increasing the activity of the parent peptide. Anoplin-chitosan conjugates were synthesized by CuAAC reaction of multiple peptides through 2-azidoacetyl groups on chitosan.
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عنوان ژورنال:
- Chemical communications
دوره 51 58 شماره
صفحات -
تاریخ انتشار 2015